Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065146 | 0.82 | KDM4E (0.54) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL5696504 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL341046 | 0.76 | NPC1 (0.58) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL29931828 | 0.76 | NPC1 (0.58) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL18702949 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL10461568 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL29502992 | 0.73 | SCN9A (0.58) | SMN1; SMN2LMNAMAPTL3MBTL1KDM4E | |
| SCHEMBL6042536 | 0.73 | KDM4E (0.49) | SMN1; SMN2LMNAMAPTL3MBTL1HTT | |
| SCHEMBL5307369 | 0.73 | SCN9A (0.58) | SMN1; SMN2LMNAMAPTL3MBTL1KDM4E | |
| SCHEMBL3944765 | 0.73 | LIG1 (0.54) | SMN1; SMN2LMNAHTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843949-A | 1-(1H-indolyloxyalkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5776963-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-07 | — | — | US | disclosed |