Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.66 |
| ▸ | HTR1B | P28222 | 9/20 | 0.66 |
| ▸ | HTR2A | P28223 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689553 | 0.92 | HTR1D (0.66) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8687447 | 0.92 | HTR1D (0.66) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8690455 | 0.92 | HTR1D (0.71) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8687745 | 0.91 | HTR1D (0.65) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8690088 | 0.91 | HTR1D (0.65) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8687606 | 0.88 | HTR1D (0.65) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8689906 | 0.84 | HTR1D (0.60) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8689921 | 0.84 | HTR1D (0.60) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8692625 | 0.84 | HTR1D (0.58) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8687965 | 0.84 | HTR1D (0.58) | HTR1DHTR1BHTR2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5801170-A | Heterocyclic biphenylylamides useful as 5HT1D antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-09-01 | — | — | US | disclosed |