Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690475 | 1.00 | MAPT (0.66) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL8819734 | 0.88 | MEN1 (0.62) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL8819723 | 0.88 | MEN1 (0.62) | MAPTMEN1KMT2ALMNAKDM4E | |
| Hydrochloric Acid SCHEMBL19747609 | 0.87 | KMT2A (0.67) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL15142972 | 0.85 | KMT2A (0.64) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL5384568 | 0.83 | MAPT (0.63) | MAPTMEN1KMT2ALMNAKDM4E | |
| Hydrochloric Acid SCHEMBL8969023 | 0.81 | MAPT (0.56) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL8820084 | 0.81 | KMT2A (0.53) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL8820097 | 0.81 | KMT2A (0.53) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL28167969 | 0.80 | MAPT (0.69) | MAPTMEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792760-A | USEFUL IN TREATMENT OF PSYCHOLOGICAL AND CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |