Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 11/20 | 0.52 |
| ▸ | FEN1 | P39748 | 11/20 | 0.52 |
| ▸ | BACE1 | P56817 | 6/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711 | 0.77 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17387526 | 0.71 | HSP90AA1 (0.64) | ALOX5APFEN1 | |
| SCHEMBL12199619 | 0.71 | HSP90AA1 (0.64) | ALOX5APFEN1 | |
| SCHEMBL9932 | 0.70 | BACE1 (0.59) | BACE1CTSDHPGDTSHR | |
| SCHEMBL15917736 | 0.70 | ALOX5AP (0.85) | ALOX5APFEN1 | |
| SCHEMBL15911249 | 0.70 | ALOX5AP (0.52) | ALOX5APFEN1HPGDTSHRRECQL | |
| SCHEMBL18059719 | 0.69 | ALOX5AP (0.60) | ALOX5APFEN1 | |
| SCHEMBL12199608 | 0.68 | HSP90AA1 (0.66) | ALOX5APFEN1HPGD | |
| SCHEMBL15915951 | 0.68 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL2509379 | 0.67 | HSP90AA1 (0.64) | ALOX5APFEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296698-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20120329830-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | AMGEN INC. (US) | 2012-12-27 | — | — | US | disclosed |
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329830-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | BACE1, BACE2, APP | ALOX5AP 1148/4885FEN1 2805/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.