Guanidine — predicted protein targets

Known targets — ChEMBL curated mechanism

KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2

The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	ACE	P12821	3/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Guanidine SCHEMBL8690711	1.00	ACE (0.47)	ACE
SCHEMBL5847071	0.91	ACE (0.54)	ACE
SCHEMBL4278365	0.91	ACE (0.54)	ACE
SCHEMBL5847068	0.91	ACE (0.54)	ACE
SCHEMBL12626587	0.83	XIAP (0.47)	ACE
Hydrochloric Acid SCHEMBL27419433	0.82	XIAP (0.38)	—
Guanidine SCHEMBL8690427	0.81	NOTUM (0.39)	—
Hydrochloric Acid SCHEMBL8690716	0.81	XIAP (0.38)	—
Hydrochloric Acid SCHEMBL8691613	0.81	XIAP (0.38)	—
SCHEMBL3365538	0.79	NOTUM (0.49)	ACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5852046-A	Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them	HOECHST AKTIENGESELLSCHAFT (DE)	1998-12-22	—	—	US	disclosed