Trifluoromethylbenzene

Trifluoromethylbenzene

SCHEMBL8692

FC(F)(F)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 1.00
ALDH1A1 P00352 1/20 1.00
KIF11 P52732 4/20 0.68
TRPV6 Q9H1D0 2/20 0.54
CYP19A1 P11511 1/20 0.50
BACE1 P56817 1/20 0.48
PTPN1 P18031 1/20 0.48
MAPK1 P28482 1/20 0.48
KCNN4 O15554 1/20 0.47
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA5A P35218 1/20 0.46
CA9 Q16790 1/20 0.46
OPRM1 P35372 1/20 0.45
OPRL1 P41146 1/20 0.45
ACP3 P15309 1/20 0.45
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL175647 1.00 TSHR (1.00) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL27760126 1.00 TSHR (1.00) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL31609597 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL31493124 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL31017025 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL7870246 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL14121761 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL14121438 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL22806921 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1
Trifluoromethylbenzene SCHEMBL9482280 0.97 TSHR (0.93) TSHRALDH1A1KIF11TRPV6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 33093 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117599617-B Chiral covalent organic framework composite membrane prepared by in-situ growth method and application thereof CHINA PHARMACEUTICAL UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122079942-A Method for organically catalyzing dynamic resolution of oxaspirorenone carbon-oxygen bond hydrogenolysis 2026-05-26 CN claimed
CN-122080089-A Method for synthesizing ferrocene isoquinoline and ferrocene dihydro isoquinoline planar chiral compounds 2026-05-26 CN claimed
CN-122079892-A Method for synthesizing chiral dihydroquinoline spiro compound by rhodium-catalyzed asymmetric dearomatization cyclization 2026-05-26 CN claimed
WO-2026107431-A1 STEREOSELECTIVE SYNTHESIS OF L,2-CIS-2-AMINOGLYCOSIDES BRANDEIS UNIVERSITY (US) 2026-05-21 WO claimed
WO-2026106777-A1 BATTERY COMPOSITIONS USING BIOGENIC ANODE MATERIALS ELEMENTIUM MATERIALS, INC. (US) 2026-05-21 WO claimed
WO-2026107383-A1 INHIBITORS OF HIF-ALPHA IN TUMOR CELLS AND METHOD OF USE THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-05-21 WO claimed
CN-122059951-A Synthesis method of Ai Shakang azole impurity 广东东阳光药业股份有限公司 2026-05-19 CN claimed
CN-122060477-A Oil displacement agent for petroleum exploitation and preparation method thereof 陕西宇航能源技术有限公司 2026-05-19 CN claimed
CN-122060385-A Anticorrosive polyester coating and preparation method thereof 扬州工业职业技术学院 2026-05-19 CN claimed
US-4031131-A 3-HYDROXYBENZOIC ACID, 3-CHLORO-4-HALOBENZOTRIFLUORIDE ROHM AND HAAS COMPANY (US) 1977-06-21 US claimed
US-4024032-A AROMATIC SUBSTRATE, CARBOXYLIC ACID HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-05-17 US claimed
US-4008278-A FROM AN AMINO-BENZOTRIFLUORIDE AND A HALOGEN SOURCE OLIN CORPORATION (US) 1977-02-15 US claimed
US-3992208-A Photo-sensitive etchant and method for forming metal image using same FUJI PHOTO FILM CO., LTD. (JA) 1976-11-16 US claimed
US-3960559-A Method of making a semiconductor device utilizing a light-sensitive etching agent FUJI PHOTO FILM CO., LTD. (JA) 1976-06-01 US claimed
US-3961023-A Process for the production of cyanogen chloride and hydrogen chloride DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1976-06-01 US claimed
US-3950445-A Process for the production of benzotrifluoride LONZA LTD. (CH) 1976-04-13 US claimed
US-3950383-A SEDATIVES, MUSCLE RELAXANTS, ANTIAGGRESSION CASSELLA FARBWERKE MAINKUR AKT (DT) 1976-04-13 US claimed
US-3947257-A BENZOTRIFLUORIDE FUEL ADDITIVE FOR INTERNAL COMBUSTION ENGINES RAYCHEM CORPORATION (US) 1976-03-30 US claimed
US-3935117-A Photosensitive etching composition FUJI PHOTO FILM CO., LTD. (JA) 1976-01-27 US claimed