Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 10/20 | 0.44 |
| ▸ | FLT4 | P35916 | 4/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | FRK | P42685 | 3/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.44 |
| ▸ | BLK | P51451 | 3/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.44 |
| ▸ | NEK2 | P51955 | 3/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | STK3 | Q13188 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868249 | 0.82 | EIF2AK3 (0.46) | KDREIF2AK3JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL869114 | 0.81 | EIF2AK3 (0.45) | KDREIF2AK3JAK2JAK3 | |
| SCHEMBL868587 | 0.78 | MAPK1 (0.39) | KDREIF2AK3FLT1TEKJAK2 | |
| SCHEMBL868609 | 0.74 | EIF2AK3 (0.52) | EIF2AK3LCKRETNTRK3AURKB | |
| Hydrochloric Acid SCHEMBL869345 | 0.74 | EIF2AK3 (0.52) | EIF2AK3LCKRETNTRK3AURKB | |
| Hydrochloric Acid SCHEMBL868202 | 0.74 | EIF2AK3 (0.52) | EIF2AK3LCKRETNTRK3AURKB | |
| SCHEMBL3120400 | 0.73 | KDR (0.71) | KDRFLT1FLT4PLK4ROCK2 | |
| SCHEMBL17749175 | 0.72 | PIK3CD (0.57) | KDRLCKRETFLT3RIPK1 | |
| SCHEMBL14014013 | 0.71 | KDR (0.57) | KDRFLT1FLT4PLK4ROCK2 | |
| SCHEMBL14013994 | 0.71 | KDR (0.68) | KDRFLT1FLT4PLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885EIF2AK3 16/4885FLT1 1094/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885EIF2AK3 16/4885FLT1 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.