Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170176 | 0.72 | KDM4E (0.52) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| SCHEMBL1445518 | 0.68 | SMN1; SMN2 (0.47) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| SCHEMBL1445699 | 0.67 | KDM4E (0.50) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| SCHEMBL14465345 | 0.67 | NPC1 (0.60) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| SCHEMBL17889739 | 0.67 | RPS6KA5 (0.45) | SMN1; SMN2KDM4ELMNAMETSLC6A4 | |
| SCHEMBL2839207 | 0.66 | HSD17B10 (0.59) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| SCHEMBL6357965 | 0.65 | TP53 (0.47) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| Dipyridyl SCHEMBL6885910 | 0.64 | KDM4E (0.93) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| Dipyridyl SCHEMBL8655605 | 0.64 | KDM4E (0.93) | NPC1TP53SMN1; SMN2TSHRKDM4E | |
| Dipyridyl SCHEMBL27971550 | 0.64 | KDM4E (0.93) | NPC1TP53SMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |