⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14855349 | 0.76 | — | — | |
| SCHEMBL7178562 | 0.70 | GSK3A (0.50) | — | |
| SCHEMBL9422467 | 0.67 | — | — | |
| SCHEMBL43230 | 0.63 | — | — | |
| SCHEMBL5323960 | 0.62 | — | — | |
| SCHEMBL8915830 | 0.62 | — | — | |
| SCHEMBL7447410 | 0.62 | — | — | |
| SCHEMBL19728852 | 0.61 | GSK3A (0.33) | — | |
| Water SCHEMBL2971807 | 0.61 | — | — | |
| SCHEMBL19720133 | 0.61 | GSK3A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256468-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | Sunshine Lake Pharma Co., Ltd. (CN) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016127924-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-08-18 | — | — | WO | disclosed |
| EP-2174939-A1 | Pyranones useful as ATM inhibitors | Kudos Pharmaceuticals Limited (GB) | 2010-04-14 | — | — | EP | disclosed |
| US-5734067-A | THERAPY FOR CANCER, ARTHEROSCLEROSIS OR LIVER DISEASES | NIPPON SUISAN KAISHA, LTD. (JP) | 1998-03-31 | — | — | US | disclosed |
| US-4535171-A | Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists | MERCK FROSST CANADA, INC. (CA) | 1985-08-13 | — | — | US | disclosed |
| EP-0138532-A2 | 3-Substituted dibenzo [b,f] thiepins, compositions containing them and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |
| EP-0029587-B1 | 3-HYDROXYMETHYLDIBENZO(B,F)THIEPINS AND DIBENZO(B,F)THIEPIN-3-CARBOXALDEHYDES AS PROSTAGLANDIN ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4334077-A | Stereospecific sulfoxidation of dibenzo thiepins | MERCK & CO., INC. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0029587-A1 | 3-Hydroxymethyldibenzo(b,f)thiepins and dibenzo(b,f)thiepin-3-carboxaldehydes as prostaglandin antagonists, process for their preparation and pharmaceutical compositions | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1981-06-03 | — | — | EP | disclosed |
| US-4237160-A | 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-12-02 | — | — | US | disclosed |