Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702207 | 0.82 | PIK3R1 (0.36) | PIK3R1PIK3CAADRB3MAOBCASP1 | |
| SCHEMBL8698099 | 0.77 | KCNA5 (0.36) | GAACASP1ALDH1A1HPGDCASP7 | |
| SCHEMBL11136545 | 0.76 | ATM (0.44) | GAAMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8696579 | 0.75 | MAOB (0.46) | MAOBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7117345 | 0.73 | MAPT (0.40) | GAAPIK3R1PIK3CAMAOBCASP1 | |
| SCHEMBL23003718 | 0.71 | GAA (0.45) | GAAPIK3CAKDM4EMEN1ALDH1A1 | |
| SCHEMBL11279506 | 0.70 | POLB (0.42) | MAOBCASP1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14602504 | 0.70 | MAPT (0.42) | MAOBCASP1KDM4EMEN1ALDH1A1 | |
| SCHEMBL3061790 | 0.69 | GAA (0.44) | GAAKDM4EMAPTHPGDBLM | |
| SCHEMBL8745914 | 0.69 | ACP3 (0.43) | GAAMEN1ALDH1A1ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |