Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.75 |
| ▸ | RET | P07949 | 6/20 | 0.75 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.75 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.75 |
| ▸ | KDR | P35968 | 4/20 | 0.75 |
| ▸ | CDK7 | P50613 | 4/20 | 0.75 |
| ▸ | SYK | P43405 | 3/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.75 |
| ▸ | FLT3 | P36888 | 3/20 | 0.75 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.75 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.75 |
| ▸ | ABL1 | P00519 | 2/20 | 0.75 |
| ▸ | LTK | P29376 | 2/20 | 0.75 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.75 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.75 |
| ▸ | MST1R | Q04912 | 2/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.75 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.75 |
| ▸ | CDK8 | P49336 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201825 | 1.00 | NTRK1 (0.75) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL7780481 | 0.92 | NTRK1 (0.83) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL5203073 | 0.87 | NTRK1 (0.75) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL18546656 | 0.86 | SYK (1.00) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL5201532 | 0.86 | NTRK1 (1.00) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL5472269 | 0.86 | NTRK1 (1.00) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL14448937 | 0.86 | NTRK1 (1.00) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL8586470 | 0.85 | NTRK1 (0.69) | NTRK1RETNTRK2NTRK3KDR | |
| SCHEMBL8586466 | 0.85 | NTRK1 (0.69) | NTRK1RETNTRK2NTRK3KDR | |
| Hydrochloric Acid SCHEMBL8527797 | 0.84 | NTRK1 (0.68) | NTRK1RETNTRK2NTRK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849710-A | Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-12-15 | — | — | US | disclosed |
| EP-0764152-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-03-26 | — | — | EP | disclosed |
| WO-1996032380-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-10-17 | — | — | WO | disclosed |