SCHEMBL8698562

SCHEMBL8698562

O=C(Cl)N1CCN(c2ccccc2F)CC1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.69
TSHR P16473 4/20 0.69
KDM4E B2RXH2 1/20 0.67
ALOX15 P16050 1/20 0.67
CYP1A2 P05177 1/20 0.67
CYP2C9 P11712 1/20 0.67
CYP2C19 P33261 1/20 0.67
KMT2A Q03164 5/20 0.65
MEN1 O00255 4/20 0.65
LMNA P02545 1/20 0.65
MAPT P10636 1/20 0.65
ALDH1A1 P00352 4/20 0.63
MAPK1 P28482 2/20 0.63
NPSR1 Q6W5P4 2/20 0.63
HSD17B10 Q99714 1/20 0.63
USP2 O75604 2/20 0.61
GAA P10253 1/20 0.61
POLB P06746 2/20 0.58
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27918174 0.86 SMN1; SMN2 (0.73) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL5234913 0.84 KDM4E (0.73) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL13453977 0.83 SMN1; SMN2 (0.69) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL28083192 0.83 SMN1; SMN2 (0.69) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL17276274 0.82 NPC1 (0.50) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL17276412 0.82 AKR1C3 (0.64) SMN1; SMN2KDM4EKMT2AMEN1LMNA
SCHEMBL25787580 0.80 GAA (0.71) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL1423351 0.79 AKR1C3 (0.63) TSHRKMT2AALDH1A1
SCHEMBL14224489 0.79 KMT2A (0.73) SMN1; SMN2TSHRKDM4EALOX15CYP1A2
SCHEMBL13417638 0.79 SMN1; SMN2 (0.63) SMN1; SMN2TSHRKDM4EALOX15CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5789412-A 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR ANTAGONISTS FOR THE CURATIVE OR PREVENTIVE TREATMENT OF PAIN, DEPRESSION, OBSESSIVE COMPULSIVE DISORDERS, ANXIETY OR PANIC ATTACK, OR CANCER PIERRE FABRE MEDICAMENT (FR) 1998-08-04 US disclosed
EP-0773937-A1 NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME PIERRE FABRE MEDICAMENT (FR) 1997-05-21 EP disclosed
WO-1996002525-A1 NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME PIERRE FABRE MEDICAMENT (FR) 1996-02-01 WO disclosed