Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551841 | 0.86 | MCL1 (0.57) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL1065625 | 0.84 | MCL1 (0.61) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL937858 | 0.81 | MCL1 (0.58) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL7339528 | 0.78 | KDM4E (0.55) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL1065472 | 0.78 | MCL1 (0.71) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL10735951 | 0.77 | MCL1 (0.65) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL5287590 | 0.76 | MCL1 (0.69) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL4615856 | 0.75 | MCL1 (1.00) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL4310466 | 0.75 | MCL1 (0.67) | MCL1KDM4EALDH1A1GPR35HPGD | |
| SCHEMBL3617512 | 0.75 | MCL1 (0.67) | MCL1KDM4EALDH1A1GPR35HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767133-A | Secondary amines as antidiabetic and antiobesity agents | PFIZER INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| US-5627200-A | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia | PFIZER INC (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0703911-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029290-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |