SCHEMBL8700567

SCHEMBL8700567

c1ccc(C(c2cc3ccccc3o2)n2cncn2)cc1

nearest known ligand 0.85

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP26A1 O43174 2/20 0.85
CYP19A1 P11511 18/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8697507 0.90 CYP19A1 (1.00) CYP26A1CYP19A1
SCHEMBL8700535 0.90 CYP19A1 (1.00) CYP26A1CYP19A1
SCHEMBL8697398 0.90 CYP19A1 (1.00) CYP26A1CYP19A1
SCHEMBL3279272 0.86 CYP19A1 (1.00) CYP26A1CYP19A1
SCHEMBL8697755 0.79 CYP19A1 (0.73) CYP26A1CYP19A1
SCHEMBL13292485 0.78 CYP19A1 (1.00) CYP26A1CYP19A1
SCHEMBL8696281 0.77 CYP19A1 (0.56) CYP26A1CYP19A1
SCHEMBL8700529 0.75 CYP19A1 (0.73) CYP26A1CYP19A1
SCHEMBL10362274 0.75 CYP19A1 (0.81) CYP26A1CYP19A1
SCHEMBL1906425 0.75 CYP19A1 (0.62) CYP26A1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO disclosed