Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR2 | P30874 | 7/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 7/20 | 0.32 |
| ▸ | LITAF | Q99732 | 7/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870301 | 1.00 | SSTR2 (0.36) | SSTR2SSTR4CYP1A2CYP3A4RIPK2 | |
| SCHEMBL16087349 | 0.91 | PIK3CA (0.33) | CYP1A2CYP3A4PIK3CATNFLITAF | |
| SCHEMBL3026847 | 0.89 | PDE4B (0.34) | CYP3A4PIK3CATNFLITAFPDE4B | |
| SCHEMBL3026844 | 0.89 | PDE4B (0.34) | CYP3A4PIK3CATNFLITAFPDE4B | |
| SCHEMBL870680 | 0.85 | TNF (0.33) | PIK3CATNFLITAFPDE4BPDE4D | |
| SCHEMBL870679 | 0.85 | TNF (0.33) | PIK3CATNFLITAFPDE4BPDE4D | |
| SCHEMBL10271672 | 0.84 | TNF (0.36) | PIK3CATNFLITAFPDE4BPDE4D | |
| SCHEMBL870772 | 0.84 | PDE4B (0.40) | SSTR2SSTR4CYP3A4RIPK2PIK3CA | |
| SCHEMBL870773 | 0.84 | PDE4B (0.40) | SSTR2SSTR4CYP3A4RIPK2PIK3CA | |
| SCHEMBL869968 | 0.83 | CYP1A2 (0.37) | SSTR2CYP1A2CYP3A4RIPK2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | SSTR2 2312/4885SSTR4 616/4885CYP1A2 266/4885 |
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | SSTR2 2312/4885SSTR4 616/4885CYP1A2 266/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | SSTR2 2478/4885SSTR4 600/4885CYP1A2 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.