Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.70 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309755 | 1.00 | PDE4B (0.70) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL8310172 | 0.82 | PDE4B (1.00) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL15421628 | 0.82 | PDE4B (1.00) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL8310174 | 0.82 | PDE4B (1.00) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL27479995 | 0.81 | PDE4B (0.54) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL27393480 | 0.81 | PDE4B (0.72) | PDE4BCISD1PDE3ADYRK1APIM1 | |
| SCHEMBL18102990 | 0.81 | CISD1 (0.57) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL27412321 | 0.80 | CISD1 (0.57) | PDE4BCISD1PDE3ADYRK1AMAOB | |
| SCHEMBL8173323 | 0.78 | CSNK2A2 (0.64) | PDE4BPDE3ADYRK1APIM1PIM2 | |
| SCHEMBL27390743 | 0.77 | NAT1 (0.64) | PDE4BCISD1PDE3ADYRK1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |