SCHEMBL8709288

SCHEMBL8709288

Cc1cnc(-c2nnc(C(F)(F)F)o2)nc1Oc1cc(C(F)(F)F)nn1C

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.46
ADORA2A P29274 1/20 0.42
ADORA1 P30542 1/20 0.42
HDAC6 Q9UBN7 2/20 0.36
TGFBR1 P36897 1/20 0.33
CYP1A2 P05177 1/20 0.33
GPR119 Q8TDV5 1/20 0.33
ALDH1A1 P00352 1/20 0.32
TYK2 P29597 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7247712 0.81 KMT2A (0.52) KMT2AADORA2AADORA1HDAC6TGFBR1
SCHEMBL5749124 0.78 KMT2A (0.48) KMT2AADORA2AADORA1TGFBR1GPR119
SCHEMBL8710420 0.77 KMT2A (0.46) KMT2AADORA2AADORA1TGFBR1GPR119
SCHEMBL7250718 0.76 ADORA2A (0.55) KMT2AADORA2AADORA1TGFBR1CYP1A2
SCHEMBL7252765 0.76 KMT2A (0.57) KMT2AADORA2AADORA1TGFBR1GPR119
SCHEMBL7467157 0.75 KMT2A (0.46) KMT2AADORA2AADORA1HDAC6TGFBR1
SCHEMBL8707006 0.74 NPSR1 (0.49) KMT2AADORA2AHDAC6CYP1A2ALDH1A1
SCHEMBL5781141 0.67 KMT2A (0.53) KMT2AADORA2AADORA1TGFBR1GPR119
SCHEMBL8932304 0.66 ADORA2A (0.51) KMT2AADORA2AADORA1HDAC6TGFBR1
SCHEMBL5778661 0.64 KMT2A (0.53) KMT2AADORA2AADORA1HDAC6TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998056789-A1 PYRIMIDINYL AZOLE HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-12-17 WO claimed
WO-1998056789-A1 PYRIMIDINYL AZOLE HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-12-17 WO disclosed