Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.63 |
| ▸ | FLT1 | P17948 | 13/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.55 |
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | KIF5B | P33176 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455017 | 0.87 | KDR (0.72) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL7460030 | 0.86 | KDR (0.71) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL7456312 | 0.84 | KDR (0.78) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL7452814 | 0.83 | KDR (0.76) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL7455973 | 0.81 | KDR (0.72) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL8707782 | 0.81 | KDR (0.58) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL7459845 | 0.80 | KDR (0.71) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL7455479 | 0.80 | KDR (0.68) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL7457036 | 0.79 | KDR (1.00) | KDRFLT1FGFR1FLT4EGFR | |
| SCHEMBL7458759 | 0.78 | KDR (0.75) | KDRFLT1FGFR1RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873319-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-28 | — | — | EP | claimed |
| WO-1997022596-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-26 | — | — | WO | claimed |