Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.53 |
| ▸ | TUBB | P07437 | 3/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.53 |
| ▸ | TYMS | P04818 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710458 | 0.87 | KDM4E (0.72) | LMNAKDM4EHSD17B10TUBB4ATUBB | |
| SCHEMBL29999562 | 0.82 | KDM4C (0.57) | KDM4EKDM4CTUBB4ATUBBTUBA3C | |
| SCHEMBL29991554 | 0.81 | CYP1A2 (0.60) | LMNAKDM4EHSD17B10MEN1USP2 | |
| SCHEMBL29736340 | 0.80 | KDM4E (0.58) | LMNAKDM4EKDM4CTUBB4ATUBB | |
| SCHEMBL7411788 | 0.80 | KDM4E (0.67) | LMNAKDM4EHSD17B10TUBB4ATUBB | |
| SCHEMBL28753716 | 0.80 | KDM4E (0.58) | LMNAKDM4EKDM4CTUBB4ATUBB | |
| SCHEMBL29900577 | 0.78 | KDM4E (1.00) | LMNAKDM4EHSD17B10TUBB4ATUBB | |
| SCHEMBL1257374 | 0.78 | KDM4E (1.00) | LMNAKDM4EHSD17B10TUBB4ATUBB | |
| SCHEMBL11248966 | 0.78 | KDM4E (0.72) | LMNAKDM4EHSD17B10TUBB4ATUBB | |
| SCHEMBL31578022 | 0.78 | CYP1A2 (0.46) | LMNAKDM4EHSD17B10KDM4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873319-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997022596-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |