Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700938 | 0.88 | CRBN (0.47) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL102816 | 0.74 | CARM1 (0.50) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL12110641 | 0.74 | CARM1 (0.50) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL8707567 | 0.73 | ESR2 (0.35) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL8707565 | 0.73 | ESR2 (0.35) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL24483956 | 0.73 | DDB1 (0.38) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL24483499 | 0.73 | DDB1 (0.38) | CRBNDDB1F2PRSS1CARM1 | |
| SCHEMBL14369929 | 0.72 | CRBN (0.46) | CRBNDDB1MAPTALDH1A1KMT2A | |
| SCHEMBL5005486 | 0.72 | CRBN (0.46) | CRBNDDB1MAPTALDH1A1GRIN1 | |
| SCHEMBL17902671 | 0.70 | DDB1 (0.54) | CRBNDDB1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693054-B1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5681858-A | Cycloalkyl hydroxyureas | PFIZER INC. (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0693054-A1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022814-A1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |