Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871088 | 1.00 | PDE4B (0.51) | PDE4BPRKAA2CNR2CYP3A4CNR1 | |
| SCHEMBL871034 | 0.94 | PDE4B (0.51) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL871033 | 0.94 | PDE4B (0.51) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL871306 | 0.93 | PDE4B (0.50) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL871305 | 0.93 | PDE4B (0.50) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL870596 | 0.92 | PDE4B (0.53) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL870595 | 0.92 | PDE4B (0.53) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL873085 | 0.91 | PDE4B (0.52) | PDE4BPRKAA2CNR2CYP3A4 | |
| SCHEMBL871787 | 0.91 | PDE4B (0.51) | PDE4BPRKAA2CNR2CYP3A4CNR1 | |
| SCHEMBL871788 | 0.91 | PDE4B (0.51) | PDE4BPRKAA2CNR2CYP3A4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885PRKAA2 1754/4885CNR2 2229/4885 |
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885PRKAA2 1754/4885CNR2 2229/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | PDE4B 2/4885PRKAA2 1416/4885CNR2 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.