SCHEMBL8712264

SCHEMBL8712264

Nc1ncnc2c1ncn2[C@H]1CCCO1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 4/20 1.00
PI4K2B Q8TCG2 4/20 1.00
PI4K2A Q9BTU6 4/20 1.00
PI4KB Q9UBF8 4/20 1.00
NFKB1 P19838 2/20 1.00
BLM P54132 2/20 1.00
TP53 P04637 1/20 1.00
CYP2C9 P11712 1/20 1.00
MAPK1 P28482 1/20 1.00
HSD17B10 Q99714 1/20 1.00
MEN1 O00255 1/20 1.00
ALDH1A1 P00352 1/20 1.00
APEX1 P27695 1/20 1.00
KMT2A Q03164 1/20 1.00
ADCY1 Q08828 1/20 1.00
CYP2C19 P33261 1/20 0.66
ADORA2A P29274 4/20 0.62
ADORA3 P0DMS8 2/20 0.62
ADORA1 P30542 2/20 0.62
ADORA2B P29275 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL896095 1.00 PI4KA (1.00) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL30352942 1.00 PI4KA (1.00) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL30988430 0.96 PI4KA (0.92) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL675830 0.96 PI4KA (0.92) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL14908001 0.84 PI4KA (0.72) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL14983401 0.83 PI4KA (0.71) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL1998927 0.83 PI4KA (0.71) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL5740769 0.83 PI4KA (0.71) PI4KAPI4K2BPI4K2API4KBNFKB1
SCHEMBL191944 0.83 PI4KA (0.71) PI4KAPI4K2BPI4K2API4KBNFKB1
Methane SCHEMBL10551641 0.82 PI4KA (0.69) PI4KAPI4K2BPI4K2API4KBNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5837871-A PHOSPHONATE DERIVATIVES; ANTITUMOR AGENTS, VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-11-17 US disclosed
US-5726174-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-03-10 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5693798-A ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-02 US disclosed
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed
EP-0398231-A2 Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1990-11-22 EP disclosed