Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630849 | 0.73 | NISCH (0.53) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL9287236 | 0.73 | NISCH (0.64) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL30873581 | 0.72 | NISCH (0.52) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL14886257 | 0.71 | NISCH (0.61) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL28654223 | 0.71 | NISCH (0.50) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL26259955 | 0.71 | NISCH (0.61) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL81650 | 0.71 | NISCH (0.59) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL1783894 | 0.71 | NISCH (0.41) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL7979075 | 0.71 | NISCH (0.50) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL26259965 | 0.70 | NISCH (0.54) | NISCHMTORADKCSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |