Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12328406 | 0.88 | HRH3 (0.49) | HRH3SLC22A6TSHRGPR84FFAR1 | |
| SCHEMBL21795201 | 0.86 | HRH3 (0.61) | HRH3LMNATSHRALDH1A1HDAC3 | |
| SCHEMBL12328359 | 0.81 | HRH3 (0.57) | HRH3SLC22A6TSHRGPR84FFAR1 | |
| SCHEMBL8684475 | 0.81 | HRH3 (0.50) | HRH3ALDH1A1KDM4EKDM6BKDM5C | |
| SCHEMBL23869714 | 0.81 | HRH3 (0.53) | HRH3LMNATSHRALDH1A1POLB | |
| SCHEMBL12631861 | 0.81 | SLC22A6 (0.46) | SLC22A6CAMK2ALMNATSHRNFKB1 | |
| SCHEMBL22828585 | 0.81 | HRH3 (0.53) | HRH3LMNATSHRALDH1A1KDM4E | |
| SCHEMBL14181449 | 0.80 | SLC22A6 (0.43) | HRH3SLC22A6LMNATSHRNFKB1 | |
| SCHEMBL12328408 | 0.79 | SLC22A6 (0.44) | HRH3SLC22A6CAMK2ALMNATSHR | |
| SCHEMBL18059195 | 0.78 | HRH3 (0.69) | HRH3ALDH1A1KMT2ANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739350-A | COMPOUNDS CAPABLE OF BEING LINKED TO MONOCLONAL ANTIBODIES FOR DELIVERY TO TARGET CELLS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-14 | — | — | US | claimed |
| EP-0527189-A1 | NOVEL CC-1065 ANALOGS | PHARMACIA & UPJOHN COMPANY (US) | 1993-02-17 | — | — | EP | claimed |
| WO-1991016324-A1 | NOVEL CC-1065 ANALOGS | THE UPJOHN COMPANY (US) | 1991-10-31 | — | — | WO | claimed |
| US-5739350-A | COMPOUNDS CAPABLE OF BEING LINKED TO MONOCLONAL ANTIBODIES FOR DELIVERY TO TARGET CELLS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| EP-0527189-A1 | NOVEL CC-1065 ANALOGS | PHARMACIA & UPJOHN COMPANY (US) | 1993-02-17 | — | — | EP | disclosed |
| WO-1991016324-A1 | NOVEL CC-1065 ANALOGS | THE UPJOHN COMPANY (US) | 1991-10-31 | — | — | WO | disclosed |