Theophylline Anhydrous

Theophylline Anhydrous

SCHEMBL8719730

Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN.[I-].[K+]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Theophylline Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A known ✓ P27815 9/20 0.77
PDE4B known ✓ Q07343 9/20 0.77
PDE4C known ✓ Q08493 9/20 0.77
PDE4D known ✓ Q08499 9/20 0.77
ADORA2A known ✓ P29274 8/20 0.77
ADORA2B known ✓ P29275 8/20 0.77
ADORA3 known ✓ P0DMS8 4/20 0.77
ADORA1 known ✓ P30542 2/20 0.77
PDE3B known ✓ Q13370 1/20 0.56
PDE3A known ✓ Q14432 1/20 0.56
CYP1A2 P05177 2/20 0.94
LMNA P02545 1/20 0.94
MAPT P10636 1/20 0.94
ATAD2 Q6PL18 1/20 0.79
PIK3CD O00329 1/20 0.77
ALPL P05186 1/20 0.77
TMIGD3 P0DMS9 1/20 0.77
CYP2C19 P33261 1/20 0.77
HIF1A Q16665 1/20 0.77
CFTR P13569 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Theophylline Anhydrous SCHEMBL5181434 0.97 CYP1A2 (1.00) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL1321168 0.97 CYP1A2 (1.00) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL5037 0.97 CYP1A2 (1.00) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL393183 0.97 CYP1A2 (1.00) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL1022085 0.95 CYP1A2 (0.97) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL7546366 0.95 CYP1A2 (0.97) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL9792548 0.95 CYP1A2 (0.97) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL11187438 0.95 CYP1A2 (0.97) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL19987964 0.95 CYP1A2 (0.97) CYP1A2LMNAMAPTATAD2PDE4A
Theophylline Anhydrous SCHEMBL28274666 0.93 CYP1A2 (0.91) CYP1A2LMNAMAPTATAD2PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5741511-A Transdermal drug delivery device for treating erectile dysfunction SAM YANG CO., LTD. (KR) 1998-04-21 US disclosed
EP-0831942-A1 TRANSDERMAL DRUG DELIVERY DEVICE FOR TREATING ERECTILE DYSFUNCTION Sam Yang Co., Ltd. (KR) 1998-04-01 EP disclosed
WO-1996032141-A1 TRANSDERMAL DRUG DELIVERY DEVICE FOR TREATING ERECTILE DYSFUNCTION SAM YANG CO., LTD. (KR) 1996-10-17 WO disclosed