Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.67 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.67 |
| ▸ | KDM4A | O75164 | 4/20 | 0.74 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.67 |
| ▸ | INSR | P06213 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CHAT | P28329 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8722937 | 1.00 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL8727750 | 0.99 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL8727754 | 0.99 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Bromide SCHEMBL10845620 | 0.97 | KDM4A (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Bromide SCHEMBL10845617 | 0.97 | KDM4A (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Iodide SCHEMBL8723083 | 0.97 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Iodide SCHEMBL8723080 | 0.97 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL10103994 | 0.96 | KDM4A (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL10340878 | 0.96 | KDM4A (0.69) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL10340827 | 0.96 | KDM4A (0.69) | KDM4AKDM2ACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713585-B1 | Z-TYPE FILMS FOR SECOND HARMONIC GENERATION | BRITISH TECH GROUP (GB) | 1998-09-30 | — | — | EP | claimed |
| US-5786089-A | Z-type films for second harmonic generation | BRITISH TECHNOLOGY GROUP LTD. (GB) | 1998-07-28 | — | — | US | claimed |
| EP-0713585-B1 | Z-TYPE FILMS FOR SECOND HARMONIC GENERATION | BRITISH TECH GROUP (GB) | 1998-09-30 | — | — | EP | disclosed |
| US-5786089-A | Z-type films for second harmonic generation | BRITISH TECHNOLOGY GROUP LTD. (GB) | 1998-07-28 | — | — | US | disclosed |