Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.48 |
| ▸ | KDM5C | P41229 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401476 | 0.89 | TSHR (0.45) | PHF8KDM2AKDM5CKDM4ELMNA | |
| SCHEMBL29661912 | 0.79 | EGLN1 (0.50) | PHF8KDM2AKDM5CKDM4EEGLN1 | |
| SCHEMBL1361646 | 0.79 | TSHR (0.43) | LMNATSHRHDAC3CYP1A2HDAC1 | |
| SCHEMBL29023627 | 0.78 | EGLN1 (0.43) | PHF8KDM2AKDM5CKDM4EEGLN1 | |
| SCHEMBL28714993 | 0.77 | EGLN1 (0.47) | PHF8KDM2AKDM5CKDM4EEGLN1 | |
| SCHEMBL8186238 | 0.76 | EGLN1 (0.41) | PHF8KDM2AKDM5CKDM4EEGLN1 | |
| SCHEMBL9345726 | 0.76 | EGLN1 (0.41) | PHF8KDM2AKDM5CKDM4EEGLN1 | |
| SCHEMBL4316216 | 0.75 | MGAM (0.36) | LMNATSHRCYP1A2NFKB1 | |
| SCHEMBL712108 | 0.75 | — | — | |
| SCHEMBL246949 | 0.75 | PHF8 (0.48) | PHF8KDM2AKDM5CKDM4EEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110636841-A | Pharmaceutical composition for preventing and treating cancer comprising malic acid-aspartic acid shuttle inhibitor and anticancer agent as active ingredients | 国立癌症研究中心 | 2019-12-31 | — | — | CN | claimed |
| US-5756824-A | Process for the preparation of carbazates | BAYER AKTIENGESELLSCHAFT (DE) | 1998-05-26 | — | — | US | disclosed |