Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.80 |
| ▸ | LMNA | P02545 | 6/20 | 0.80 |
| ▸ | GAA | P10253 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | TOP2A | P11388 | 5/20 | 0.80 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.80 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.80 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etoposide Phosphate SCHEMBL13524290 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL29564759 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL15118344 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL1649994 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL3621 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL13318053 | 0.95 | CYP3A4 (0.83) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| SCHEMBL15395274 | 0.94 | CYP3A4 (0.81) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL29711333 | 0.93 | CYP3A4 (0.81) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| Etoposide Phosphate SCHEMBL1418871 | 0.93 | CYP3A4 (0.81) | CYP3A4LMNAGAASMN1; SMN2TOP2A | |
| SCHEMBL13529268 | 0.93 | CYP3A4 (0.81) | CYP3A4LMNAGAASMN1; SMN2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540859-B1 | Anthracycline prodrugs | BRISTOL MYERS SQUIBB CO (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0302473-B1 | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells | BRISTOL MYERS SQUIBB CO (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0540859-A1 | Anthracycline prodrugs | Bristol-Myers Squibb Company (US) | 1993-05-12 | — | — | EP | disclosed |
| US-4975278-A | Converting the prodrug at the tumor site to the active drug by means of the conjugate bound to a tumor surface antigen | BRISTOL-MYERS COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0302473-A2 | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells | Bristol-Myers Squibb Company (US) | 1989-02-08 | — | — | EP | disclosed |