Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872783 | 1.00 | PDE4B (0.45) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| SCHEMBL871390 | 0.96 | PDE4B (0.49) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| SCHEMBL871391 | 0.96 | PDE4B (0.49) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| Hydrochloric Acid SCHEMBL3026834 | 0.95 | PDE4B (0.49) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| Hydrochloric Acid SCHEMBL3026833 | 0.95 | PDE4B (0.49) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| SCHEMBL870786 | 0.92 | PDE4B (0.46) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| SCHEMBL870787 | 0.92 | PDE4B (0.46) | PDE4BHPGDSEGLN1KCNH2PDE4D | |
| SCHEMBL870870 | 0.92 | PDE4B (0.50) | PDE4BHPGDSKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3011847 | 0.92 | PDE4B (0.50) | PDE4BHPGDSKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3032496 | 0.92 | PDE4B (0.44) | PDE4BHPGDSEGLN1KCNH2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885HPGDS 351/4885EGLN1 1901/4885 |
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885HPGDS 351/4885EGLN1 1901/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | PDE4B 2/4885HPGDS 784/4885EGLN1 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.