Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.30 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.30 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.30 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728694 | 1.00 | TSHR (0.34) | TSHRLPAR1LPAR3PRKD3PRKCG | |
| SCHEMBL8728587 | 0.79 | — | — | |
| SCHEMBL8728600 | 0.79 | — | — | |
| SCHEMBL16408077 | 0.78 | TSHR (0.35) | TSHRCYP3A4 | |
| SCHEMBL30297390 | 0.76 | TSHR (0.48) | TSHRCYP3A4 | |
| SCHEMBL5520472 | 0.76 | TSHR (0.48) | TSHRCYP3A4 | |
| SCHEMBL5520469 | 0.76 | TSHR (0.48) | TSHRCYP3A4 | |
| SCHEMBL10170027 | 0.76 | TSHR (0.48) | TSHRCYP3A4 | |
| SCHEMBL10597400 | 0.71 | TSHR (0.40) | TSHRLPAR1LPAR3PRKD3PRKCG | |
| SCHEMBL4293263 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |