Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.62 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.62 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.51 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729038 | 1.00 | MAPK1 (0.68) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8766963 | 0.91 | MAPK1 (0.75) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8766966 | 0.91 | MAPK1 (0.75) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8669921 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8672966 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8672970 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8729704 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8673078 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8729700 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM | |
| SCHEMBL8669919 | 0.90 | MAPK1 (0.64) | MAPK1TDP1MAPTPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756493-A | ACTIVE AGAINST METHICILLIN RESISTANT BACTERIA | MICROCIDE PHARMACEUTICALS, INC. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5698547-A | 7-(ACYLAMINO)-3-(ARYLTHIO)-3-CEPHEM-4-CARBOXYLIC ACIDS WHICH EXHIBIT ANTIBACTERIAL ACTIVITY AGAINST ORGANISMS RESISTANT TO BETA-LACTAM ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5593986-A | Cephalosporin antibiotics | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-01-14 | — | — | US | disclosed |