Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17594377 | 0.93 | DHODH (0.56) | DHODHDHFRALKBH5 | |
| SCHEMBL8732564 | 0.91 | DHODH (0.68) | DHODHDHFRALKBH5 | |
| SCHEMBL17594047 | 0.88 | DHODH (0.64) | DHODHDHFRALKBH5 | |
| SCHEMBL8793822 | 0.86 | DHODH (0.53) | DHODHAKR1B10 | |
| SCHEMBL8730759 | 0.85 | DHODH (0.72) | DHODHDHFRALKBH5 | |
| SCHEMBL17593933 | 0.85 | PTGFR (0.55) | DHODH | |
| SCHEMBL17594351 | 0.84 | PTGFR (0.53) | — | |
| SCHEMBL6670043 | 0.83 | DHODH (0.71) | DHODHDHFRALKBH5 | |
| SCHEMBL17593675 | 0.82 | PTGFR (0.50) | DHODH | |
| SCHEMBL8730770 | 0.82 | DHODH (0.81) | DHODHDHFRALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537191-B1 | TREATMENT OF ORGAN TRANSPLANTATION REJECTION | DU PONT MERCK PHARMA (US) | 1998-04-29 | — | — | EP | claimed |
| EP-0339485-B1 | 4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL AS IMMUNOSUPPRESSIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-31 | — | — | EP | claimed |
| EP-0339484-B1 | 4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING SKIN AND MUCO-EPITHELIAL DISEASES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-01-20 | — | — | EP | claimed |
| EP-0133244-B1 | PHENYLQUINOLINECARBOXYLIC ACIDS AND DERIVATIVES AS ANTITUMOR AGENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-12-05 | — | — | EP | claimed |