Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088855 | 0.93 | PDE4B (0.50) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL682651 | 0.93 | PDE4B (0.50) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL682919 | 0.93 | PDE4B (0.50) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL2141419 | 0.93 | PDE4B (0.50) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL2085532 | 0.93 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL874372 | 0.93 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL683245 | 0.93 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL682949 | 0.93 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL683288 | 0.92 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C | |
| SCHEMBL682540 | 0.92 | PDE4B (0.49) | PDE4BPDE4ANR1H2NR1H3PDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989188-B1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2015-07-22 | — | — | EP | claimed |
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |