Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paroxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | GRK2 | P25098 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paroxetine SCHEMBL29358021 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL2583823 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL114238 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL10643985 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL1286957 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL15855060 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL1560678 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL27799 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL1945816 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 | |
| Paroxetine SCHEMBL10643980 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2SLC6A4TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5788986-A | Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression using R enantiomers, S enantiomers, and racemic mixtures of selective serotonin reuptake inhibitor compounds or their active metabolites | TRUSTEES OF TUFTS COLLEGE (US) | 1998-08-04 | — | — | US | disclosed |