Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736469 | 0.93 | CYSLTR1 (0.72) | CYSLTR1ALOX5PDE4APDE4BPDE4C | |
| SCHEMBL8736498 | 0.86 | CYSLTR1 (0.63) | CYSLTR1POLB | |
| SCHEMBL8734143 | 0.85 | CYSLTR1 (0.86) | CYSLTR1POLBADAMTS4 | |
| SCHEMBL8736040 | 0.82 | CYSLTR1 (0.60) | CYSLTR1POLB | |
| SCHEMBL7810130 | 0.81 | CYSLTR1 (0.79) | CYSLTR1ALOX5AP | |
| SCHEMBL8733699 | 0.80 | CYSLTR1 (0.70) | CYSLTR1ALOX5PDE4APDE4BPDE4C | |
| SCHEMBL8732678 | 0.79 | CYSLTR1 (0.66) | CYSLTR1ALOX5PDE4APDE4BPDE4C | |
| SCHEMBL8736452 | 0.79 | CYSLTR1 (0.74) | CYSLTR1 | |
| SCHEMBL8735635 | 0.78 | CYSLTR1 (0.68) | CYSLTR1ALOX5PDE4APDE4BPDE4C | |
| SCHEMBL3271439 | 0.78 | CYSLTR1 (0.76) | CYSLTR1ALOX5ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |