Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736103 | 0.90 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL7092704 | 0.89 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8736505 | 0.85 | CYSLTR1 (0.53) | CYSLTR1GPBAR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL7092083 | 0.82 | CYSLTR1 (0.61) | CYSLTR1GPBAR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7095202 | 0.81 | CYSLTR1 (0.70) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL1713703 | 0.80 | CYP1A2 (0.47) | — | |
| SCHEMBL10512475 | 0.79 | PDE10A (0.77) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL7094826 | 0.78 | FFAR1 (0.45) | CYSLTR1GPBAR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL8735648 | 0.78 | CYSLTR1 (0.78) | CYSLTR1GPBAR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL5904001 | 0.77 | PDE10A (0.44) | CYSLTR1GPBAR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |