⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8734690 | 1.00 | — | — | |
| SCHEMBL9628635 | 1.00 | — | — | |
| SCHEMBL9260380 | 0.76 | CHRM2 (0.50) | — | |
| SCHEMBL9260377 | 0.76 | CHRM2 (0.50) | — | |
| Hydrochloric Acid SCHEMBL9257066 | 0.75 | CHRM2 (0.49) | — | |
| Hydrochloric Acid SCHEMBL9257070 | 0.75 | CHRM2 (0.49) | — | |
| Hydrochloric Acid SCHEMBL194267 | 0.73 | CHRM2 (0.47) | — | |
| SCHEMBL12043329 | 0.72 | CHRM3 (0.34) | — | |
| SCHEMBL9361868 | 0.71 | — | — | |
| SCHEMBL11580392 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998030243-A1 | ACETYLCHOLINESTERASE INHIBITORS IN COMBINATION WITH MUSCARINIC AGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-07-16 | — | — | WO | disclosed |
| US-5532375-A | Process for preparing 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oximes | ROUSSEL-UCLAF (FR) | 1996-07-02 | — | — | US | disclosed |
| US-5532375-A | Process for preparing 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oximes | ROUSSEL-UCLAF (FR) | 1996-07-02 | — | — | US | disclosed |
| US-5391754-A | Oximination a tetrahydropyridin-3-aldehyde, alkylation with a halides, salt formation | ROUSSEL UCLAF (FR) | 1995-02-21 | — | — | US | disclosed |
| US-5391754-A | Oximination a tetrahydropyridin-3-aldehyde, alkylation with a halides, salt formation | ROUSSEL UCLAF (FR) | 1995-02-21 | — | — | US | disclosed |
| EP-0457680-B1 | Derivatives of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde oxime, process for their preparation and their use as medicaments | ROUSSEL UCLAF (FR) | 1994-12-07 | — | — | EP | disclosed |
| US-5219872-A | Treating Alzheimer*s disease, memory disorders | ROUSSEL UCLAF (FR) | 1993-06-15 | — | — | US | disclosed |
| US-5219872-A | Treating Alzheimer*s disease, memory disorders | ROUSSEL UCLAF (FR) | 1993-06-15 | — | — | US | disclosed |
| US-5204479-A | DERIVATIVES OF 1,2,5,6-TETRAHYDROPYRIDIN-3-CARBOXALDEHYDE OXIME | ROUSSEL UCLAF (FR) | 1993-04-20 | — | — | US | disclosed |
| US-5204479-A | DERIVATIVES OF 1,2,5,6-TETRAHYDROPYRIDIN-3-CARBOXALDEHYDE OXIME | ROUSSEL UCLAF (FR) | 1993-04-20 | — | — | US | disclosed |
| EP-0308283-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0457680-A1 | Derivatives of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde oxime, process for their preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1991-11-21 | — | — | EP | disclosed |
| EP-0452170-A1 | 1,2,5,6-Tetrahydropyridin-3-carboxaldehyde oxime derivatives, process for their preparation and their use as drugs | ROUSSEL-UCLAF (FR) | 1991-10-16 | — | — | EP | disclosed |
| EP-0452170-A1 | 1,2,5,6-Tetrahydropyridin-3-carboxaldehyde oxime derivatives, process for their preparation and their use as drugs | ROUSSEL-UCLAF (FR) | 1991-10-16 | — | — | EP | disclosed |
| US-4927837-A | TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA, OR MEMORY DISORDERS IN THE AGED | ROUSSEL UCLAF (FR) | 1990-05-22 | — | — | US | disclosed |
| EP-0308283-A1 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |
| EP-0308284-A1 | 1,2,5,6-Tetrahydropyridine oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |
| EP-0239445-A3 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES | — | 1989-01-18 | — | — | EP | disclosed |
| EP-0239445-A2 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1987-09-30 | — | — | EP | disclosed |
| EP-0239445-A2 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1987-09-30 | — | — | EP | disclosed |