Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.86 |
| ▸ | JAK1 | P23458 | 2/20 | 0.86 |
| ▸ | JAK3 | P52333 | 2/20 | 0.86 |
| ▸ | JAK2 | O60674 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737499 | 1.00 | SYK (0.86) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735048 | 0.93 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735047 | 0.93 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735983 | 0.93 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL13604967 | 0.90 | SYK (0.84) | SYKJAK1JAK3JAK2 | |
| SCHEMBL10242636 | 0.87 | SYK (0.89) | SYKJAK1JAK3JAK2 | |
| SCHEMBL736676 | 0.86 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735989 | 0.86 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735988 | 0.86 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735974 | 0.85 | SYK (1.00) | SYKJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186783-A1 | INHIBITORS OF PROTEIN KINASES | ALEXION PHARMACEUTICALS, INC. | 2018-07-05 | — | — | US | disclosed |
| US-8937070-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-01-20 | — | — | US | disclosed |
| US-20140031361-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. | 2014-01-30 | — | — | US | disclosed |
| US-8501944-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120129867-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129867-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | SYK 1/4885JAK1 3/4885JAK3 7/4885 |
| US-20180186783-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | SYK 1/4885JAK1 3/4885JAK3 7/4885 |
| US-20140031361-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | SYK 1/4885JAK1 3/4885JAK3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.