Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18224153 | 0.95 | NPC1 (0.50) | NPC1RAB9AHPGDCYP3A4LMNA | |
| SCHEMBL29385429 | 0.91 | SERPINE1 (0.49) | NPC1RAB9AHPGDLMNAPOLB | |
| SCHEMBL93564 | 0.91 | SERPINE1 (0.49) | NPC1RAB9AHPGDLMNAPOLB | |
| SCHEMBL15224330 | 0.89 | NPC1 (0.46) | NPC1RAB9AHPGDCYP3A4LMNA | |
| SCHEMBL93256 | 0.89 | HPGD (0.56) | NPC1RAB9AHPGDCYP3A4LMNA | |
| SCHEMBL380884 | 0.87 | HPGD (0.54) | NPC1RAB9AHPGDCYP3A4LMNA | |
| SCHEMBL22899522 | 0.86 | POLB (0.54) | POLBMAPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL93397 | 0.85 | HPGD (0.59) | HPGDCYP3A4LMNACYP1A2PGR | |
| SCHEMBL29384880 | 0.85 | HPGD (0.59) | HPGDCYP3A4LMNACYP1A2PGR | |
| SCHEMBL22899541 | 0.85 | POLB (0.47) | POLBMAPTL3MBTL1HTTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647143-B1 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING & MFG (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0647143-A1 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-04-12 | — | — | EP | claimed |
| US-5292514-A | Hydrogel coupled to biologically active material through azalactone moiety | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-03-08 | — | — | US | claimed |
| WO-1994000165-A2 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-01-06 | — | — | WO | claimed |
| EP-0647143-B1 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING & MFG (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0407932-B1 | UV light-absorbing skin-protecting composition | SHIONOGI & CO (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0647143-A1 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5292514-A | Hydrogel coupled to biologically active material through azalactone moiety | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-03-08 | — | — | US | disclosed |
| WO-1994000165-A2 | AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-01-06 | — | — | WO | disclosed |
| US-5063048-A | Acrylic ester or amide polymers | SHIONOGI & CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |