Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738568 | 0.86 | EZH2 (0.66) | EZH2KMT2AMEN1 | |
| SCHEMBL8739405 | 0.86 | EZH2 (0.66) | EZH2L3MBTL1KMT2AMEN1 | |
| SCHEMBL8739476 | 0.86 | EZH2 (0.63) | EZH2SMN1; SMN2L3MBTL1KMT2AMEN1 | |
| SCHEMBL8738114 | 0.85 | EZH2 (0.70) | EZH2MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL8738927 | 0.84 | EZH2 (0.61) | EZH2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8738688 | 0.82 | EZH2 (0.69) | EZH2MAPTRAB9AL3MBTL1LMNA | |
| SCHEMBL8738171 | 0.82 | EZH2 (0.74) | EZH2KMT2AMEN1 | |
| SCHEMBL8738175 | 0.81 | EZH2 (0.73) | EZH2L3MBTL1KMT2AMEN1 | |
| SCHEMBL8738586 | 0.81 | EZH2 (0.73) | EZH2MAPT | |
| SCHEMBL8739400 | 0.80 | EZH2 (0.66) | EZH2KDM4EMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |