Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.47 |
| ▸ | TNK1 | Q13470 | 5/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160552 | 0.91 | PARP1 (0.53) | PARP1TNK1 | |
| SCHEMBL1160945 | 0.88 | PARP1 (0.47) | PARP1TNK1TNK2 | |
| SCHEMBL1160719 | 0.83 | PARP1 (0.56) | PARP1TNK1TNK2 | |
| SCHEMBL1160913 | 0.82 | PARP1 (0.55) | PARP1TNK1 | |
| SCHEMBL1160521 | 0.81 | PARP1 (0.55) | PARP1TNK1TNK2 | |
| SCHEMBL1160597 | 0.81 | PARP1 (0.54) | PARP1TNK1 | |
| SCHEMBL1160946 | 0.81 | PARP1 (0.54) | PARP1TNK1 | |
| SCHEMBL1160972 | 0.81 | PARP1 (0.54) | PARP1 | |
| SCHEMBL1160966 | 0.81 | PARP1 (0.54) | PARP1TNK1TNK2 | |
| SCHEMBL1160678 | 0.80 | PARP1 (0.53) | PARP1TNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541417-B2 | Poly (ADP-ribose) polymerase (PARP) inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-09-24 | — | — | US | disclosed |
| US-8541417-B2 | Poly (ADP-ribose) polymerase (PARP) inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-09-24 | — | — | US | disclosed |
| US-20120129868-A1 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
| US-20120129868-A1 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129868-A1 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885TNK1 1808/4885TNK2 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.