Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.78 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738260 | 0.92 | EZH2 (0.79) | EZH2SCN9A | |
| SCHEMBL8739215 | 0.90 | EZH2 (0.79) | EZH2 | |
| SCHEMBL8739029 | 0.89 | EZH2 (0.84) | EZH2 | |
| SCHEMBL6120703 | 0.88 | EZH2 (1.00) | EZH2 | |
| SCHEMBL8739715 | 0.88 | EZH2 (0.83) | EZH2 | |
| SCHEMBL8739339 | 0.87 | EZH2 (0.75) | EZH2SCN9A | |
| SCHEMBL8739278 | 0.87 | EZH2 (0.76) | EZH2 | |
| SCHEMBL8739382 | 0.86 | EZH2 (0.71) | EZH2PTK2 | |
| SCHEMBL8738914 | 0.86 | EZH2 (0.73) | EZH2SCN9APTK2 | |
| SCHEMBL8738951 | 0.86 | EZH2 (0.77) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |