Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 19/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738930 | 0.90 | EZH2 (0.84) | EZH2ROCK2ROCK1 | |
| SCHEMBL8738622 | 0.89 | EZH2 (1.00) | EZH2 | |
| SCHEMBL8739453 | 0.89 | EZH2 (0.83) | EZH2 | |
| SCHEMBL8739666 | 0.89 | EZH2 (0.83) | EZH2 | |
| SCHEMBL8739029 | 0.81 | EZH2 (0.84) | EZH2ROCK2ROCK1 | |
| SCHEMBL8739385 | 0.80 | EZH2 (0.71) | EZH2 | |
| SCHEMBL8738587 | 0.79 | EZH2 (0.73) | EZH2 | |
| SCHEMBL8738987 | 0.79 | EZH2 (0.84) | EZH2 | |
| SCHEMBL8739078 | 0.79 | EZH2 (0.84) | EZH2 | |
| SCHEMBL6120847 | 0.79 | EZH2 (1.00) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |