Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163805 | 0.98 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1MMP14IDO1PSMB5 | |
| SCHEMBL3806197 | 0.79 | — | — | |
| SCHEMBL31540633 | 0.79 | — | — | |
| SCHEMBL378661 | 0.79 | FGFR1 (0.30) | — | |
| SCHEMBL2995564 | 0.76 | DPP4 (0.36) | HSP90AA1MMP14 | |
| SCHEMBL1021251 | 0.76 | KDM4E (0.37) | — | |
| SCHEMBL5702764 | 0.76 | KDM4E (0.34) | HSP90AA1 | |
| SCHEMBL3469279 | 0.76 | PDPK1 (0.32) | — | |
| SCHEMBL27510266 | 0.76 | HSP90AA1 (0.32) | HSP90AA1HSP90AB1IDO1PSMB5 | |
| SCHEMBL2291635 | 0.76 | RPS6KA3 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-03 | — | — | US | disclosed |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2020-12-31 | — | — | US | disclosed |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2020-10-13 | — | — | US | disclosed |
| EP-2912032-B1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2020-05-27 | — | — | EP | disclosed |
| US-20190330151-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2019-10-31 | — | — | US | disclosed |
| EP-2454236-B1 | 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-09-04 | — | — | EP | disclosed |
| US-10385018-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-08-20 | — | — | US | disclosed |
| WO-2019035037-A1 | CLEANING KIT | THE PROCTER & GAMBLE COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |
| US-9670191-B2 | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-06-06 | — | — | US | disclosed |
| EP-2454237-B1 | 3-OXO-2,3,-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-09-07 | — | — | EP | disclosed |
| US-20020055070-A1 | Silver halide photographic light-sensitive material and method of forming image therein | FUJI PHOTO FILM CO., LTD. | 2002-05-09 | — | — | US | disclosed |
| US-20020031731-A1 | Method of processing silver halide color photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2002-03-14 | — | — | US | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |
| EP-1162503-A2 | Method of processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2001-12-12 | — | — | EP | disclosed |
| JP-2000178263-A | NEW BISBENZOTRIAZOLYLAMIDE COMPOUND, AND HEAT-SENSITIVE RECORDING MATERIAL CONTAINING THE SAME | NIPPON PAPER INDUSTRIES CO LTD | 2000-06-27 | — | — | JP | disclosed |
| US-5760248-A | HAVING IMPROVED METABOLIC STABILITY | A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-06-02 | — | — | US | disclosed |
| EP-0131161-B1 | HEAT-DEVELOPABLE COLOR PHOTOSENSITIVE ELEMENT | KONICA CORPORATION (JP) | 1988-11-02 | — | — | EP | disclosed |
| US-4770989-A | USING A THERMAL SOLVENT AND GELATIN/POLYVINYPYRROLIDONE POLYMER MIXTURE; DIFFUSION TRANSFER QUALITY IMAGE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0131161-A2 | Heat-developable color photosensitive element | KONICA CORPORATION (JP) | 1985-01-16 | — | — | EP | disclosed |
| US-4451561-A | Heat-development-type image recording material | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP12 | HSP90AA1 2035/4885HSP90AB1 1757/4885MMP14 1519/4885 |
| US-20190330151-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | HSP90AA1 1407/4885HSP90AB1 1126/4885MMP14 1740/4885 |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP11 | HSP90AA1 1407/4885HSP90AB1 1126/4885MMP14 1740/4885 |
| US-10385018-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP11 | HSP90AA1 2066/4885HSP90AB1 1727/4885MMP14 1037/4885 |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | HSP90AA1 1395/4885HSP90AB1 1113/4885MMP14 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.