Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 1.00 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738695 | 0.95 | EZH2 (0.91) | EZH2SLC2A1 | |
| SCHEMBL8738237 | 0.90 | EZH2 (0.81) | EZH2SLC2A1MAPTALDH1A1MEN1 | |
| SCHEMBL8738962 | 0.90 | EZH2 (0.81) | EZH2SLC2A1MAPTALDH1A1MEN1 | |
| SCHEMBL8738221 | 0.89 | EZH2 (0.80) | EZH2SLC2A1MAPTMEN1KMT2A | |
| SCHEMBL6120934 | 0.89 | EZH2 (0.80) | EZH2SLC2A1MAPTMEN1KMT2A | |
| SCHEMBL8739028 | 0.89 | EZH2 (0.80) | EZH2SLC2A1MAPTSLC6A5MEN1 | |
| SCHEMBL8738305 | 0.88 | EZH2 (0.79) | EZH2MEN1KMT2APOLB | |
| SCHEMBL6121036 | 0.88 | EZH2 (0.78) | EZH2MEN1KMT2APOLB | |
| SCHEMBL8739377 | 0.88 | EZH2 (0.78) | EZH2SLC2A1MEN1KMT2A | |
| SCHEMBL8739015 | 0.88 | EZH2 (0.77) | EZH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |