Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739046 | 0.89 | EZH2 (0.73) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739283 | 0.84 | EZH2 (0.76) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739649 | 0.82 | EZH2 (0.70) | EZH2MEN1KMT2A | |
| SCHEMBL8738112 | 0.82 | EZH2 (0.79) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8738936 | 0.80 | EZH2 (0.65) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739674 | 0.78 | EZH2 (0.73) | EZH2 | |
| SCHEMBL8738587 | 0.78 | EZH2 (0.73) | EZH2GLA | |
| SCHEMBL8738188 | 0.78 | EZH2 (1.00) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739385 | 0.77 | EZH2 (0.71) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739017 | 0.76 | EZH2 (0.69) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |