Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.67 |
| ▸ | CCR8 | P51685 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739440 | 0.99 | EZH2 (0.66) | EZH2CCR8DRD4CHRM4SLC2A1 | |
| SCHEMBL8739277 | 0.92 | EZH2 (0.64) | EZH2CCR8DRD4KMT2A | |
| SCHEMBL8738589 | 0.86 | EZH2 (0.75) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738269 | 0.84 | EZH2 (0.72) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738278 | 0.83 | EZH2 (0.71) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738676 | 0.82 | EZH2 (0.67) | EZH2 | |
| SCHEMBL8739015 | 0.81 | EZH2 (0.77) | EZH2L3MBTL1SLC2A1 | |
| SCHEMBL8738591 | 0.81 | EZH2 (1.00) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738562 | 0.81 | EZH2 (0.80) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738134 | 0.81 | EZH2 (0.80) | EZH2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |