Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 16/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739265 | 0.90 | EZH2 (0.64) | EZH2MEN1KMT2A | |
| SCHEMBL8739221 | 0.89 | EZH2 (0.59) | EZH2MEN1KMT2AMITFRAD52 | |
| SCHEMBL8738125 | 0.85 | EZH2 (0.67) | EZH2MEN1KMT2A | |
| SCHEMBL8739024 | 0.84 | EZH2 (0.69) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6119756 | 0.83 | EZH2 (0.77) | EZH2MEN1KMT2A | |
| SCHEMBL8739271 | 0.82 | EZH2 (0.60) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8739464 | 0.82 | EZH2 (0.54) | EZH2MEN1KMT2A | |
| SCHEMBL8738991 | 0.81 | EZH2 (0.61) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738659 | 0.81 | EZH2 (0.53) | EZH2MEN1KMT2A | |
| SCHEMBL8738990 | 0.81 | EZH2 (0.66) | EZH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |