Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738274 | 0.89 | EZH2 (0.72) | EZH2GLA | |
| SCHEMBL8739359 | 0.84 | EZH2 (0.77) | EZH2GLAKDM4EGAAMEN1 | |
| SCHEMBL8739397 | 0.82 | EZH2 (0.63) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL8738600 | 0.81 | EZH2 (0.78) | EZH2 | |
| SCHEMBL8738610 | 0.79 | EZH2 (0.72) | EZH2GLA | |
| SCHEMBL8739466 | 0.78 | EZH2 (0.73) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739283 | 0.78 | EZH2 (0.76) | EZH2GLAMEN1KMT2A | |
| SCHEMBL8739013 | 0.77 | EZH2 (0.66) | EZH2L3MBTL1 | |
| SCHEMBL6119756 | 0.77 | EZH2 (0.77) | EZH2MEN1KMT2A | |
| SCHEMBL8738256 | 0.77 | EZH2 (0.72) | EZH2GLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |