Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739264 | 0.88 | EZH2 (0.55) | EZH2KMT2AMEN1 | |
| SCHEMBL8738991 | 0.87 | EZH2 (0.61) | EZH2KMT2AMEN1 | |
| SCHEMBL8739464 | 0.85 | EZH2 (0.54) | EZH2KMT2AMEN1 | |
| SCHEMBL8739024 | 0.84 | EZH2 (0.69) | EZH2KMT2AMEN1 | |
| SCHEMBL8739213 | 0.84 | EZH2 (0.59) | EZH2KMT2AMEN1 | |
| SCHEMBL8738595 | 0.84 | EZH2 (0.59) | EZH2KMT2AMEN1 | |
| SCHEMBL8738659 | 0.83 | EZH2 (0.53) | EZH2KMT2AMEN1 | |
| SCHEMBL8738593 | 0.83 | EZH2 (0.59) | EZH2KMT2AMEN1 | |
| SCHEMBL8739747 | 0.82 | EZH2 (0.58) | EZH2KMT2AMEN1 | |
| SCHEMBL6119756 | 0.82 | EZH2 (0.77) | EZH2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |